Research use only (RUO): Qualified laboratory research only — not for human or veterinary use. Statement

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Research guide

AICAR (AICA Ribonucleotide)

AMPK activator and nucleotide metabolism probe for energy sensing research. ≥98% purity, COA. RUO only.

By · Reviewed · Editorial standards

Short answer

AICAR (AICA Ribonucleotide) is supplied by HALO as a research-use-only lyophilized compound for qualified laboratory research. AMPK activator and nucleotide metabolism probe for energy sensing research. ≥98% purity, COA. RUO only.

  • Molecular weight: 338.21 g/mol
  • CAS: 2627-69-2
  • Documentation: 98%+ HPLC purity, independent COA, lot-indexed records
  • Use limitation: Research use only; not for human or veterinary use

Diagrams

MitoNAD+ROSImmuneResearch pathway (RUO model)
Research pathway context (schematic)
HALO · IDENTITYAICAR (AICA RibonucleoCAS: 2627-69-2MW: 338.21 g/molPurity ≥98% HPLC · Lyophilized · RUO only
Identity card
VialLot matchHPLCLC-MSBatch-specific COA chain
COA verification flow
Lyophilized handling (lab)−20 °CDry/sealed→Reconst.Diluent→2–8 °CShort holdResearch stock prep only · not dosing guidance
Lyophilized handling workflow

Mechanism of action in research models

AICAR (AICA Ribonucleotide) is used in longevity, mitochondrial, immune-modulatory, and cellular stress research programmes. Typical endpoints include mitochondrial membrane potential, ROS production, NAD+/NADH ratios, senescence-associated markers, and innate immune signalling in cell culture or animal models. Mitochondria-targeted peptides may interact with cardiolipin or inner-membrane components; thymic peptides modulate T-cell differentiation pathways in immunology research.

All HALO longevity-cluster materials are RUO reference compounds. Experimental design should separate biochemical mechanism data from any clinical extrapolation.

Research background

Longevity research increasingly relies on well-characterised peptide tool compounds with documented purity and identity. AICAR (AICA Ribonucleotide) is supplied with independent COA verification so laboratories can cite batch-specific analytical data in methods sections and procurement audits.

Documentation and COA standards

Each HALO lot of AICAR (AICA Ribonucleotide) ships with an independent certificate of analysis documenting:

  • HPLC purity — reverse-phase chromatography with ≥98% main peak by area integration
  • Identity confirmation — LC-MS, ESI-MS, or MALDI-TOF as applicable to molecular weight
  • Lot / batch number — must match the vial label for procurement audit trails
  • Test date and method — third-party laboratory, not supplier self-reporting

Read: What is a peptide COA? · Batch-specific verification · Lab results index

Storage and handling

Store lyophilized AICAR (AICA Ribonucleotide) sealed, cold (−20 °C), dry, and protected from light until reconstitution. After reconstitution with an appropriate research diluent, follow institutional stability protocols; minimise freeze-thaw cycles and document open-vial dates in the lab log.

Tools: Peptide calculator · Lyophilized peptide guide · Stability guide

Frequently asked research questions

What is AICAR (AICA Ribonucleotide) used for in research?
AICAR (AICA Ribonucleotide) is a research-use-only reference material studied in qualified laboratory models related to Mitochondrial · immune · senescence · redox pathways. HALO supplies it with batch COA documentation for procurement and methods citation. Not for human or veterinary use.
What documentation ships with AICAR (AICA Ribonucleotide)?
Each order includes a lot-specific certificate of analysis with HPLC purity, identity confirmation where applicable, batch number, and test date. Digital verification is available via the product page and /lab-results/.
How is purity verified for AICAR (AICA Ribonucleotide)?
Independent third-party HPLC confirms ≥98% main peak purity. Identity is confirmed by mass spectrometry when molecular weight permits. Results are lot-specific — not generic catalogue COAs.
What does RUO mean for this listing?
Research Use Only: AICAR (AICA Ribonucleotide) is sold for qualified in-vitro and laboratory research. It is not for human or veterinary use, diagnosis, treatment, or clinical administration.
How should lyophilized AICAR (AICA Ribonucleotide) be stored?
Keep sealed at −20 °C, desiccated, protected from light. After reconstitution, follow your institutional SOP; typical short-term storage is 2–8 °C with limited hold time depending on diluent and compound stability.
Where can the COA be verified?
Match the lot number on your vial to the COA included with your shipment. For a digital copy or institutional packet, email [email protected] with your order number and lot ID.

Related research guides

  • NAD+ — Redox coenzyme and sirtuin / PARP / CD38 substrate — central to ageing & metabolic research.
  • MOTS-c — Mitochondria-derived peptide — AMPK activation via folate/AICAR, age-dependent decline, "exercise mimetic" research.
  • Epithalon — Synthetic pineal tetrapeptide — telomerase / hTERT, melatonin rhythm, antioxidant research.
  • SS-31 (Elamipretide) — Mitochondria-targeted tetrapeptide for cardiolipin protection and oxidative stress research. ≥98% purity, COA. RUO only.

Selected references

  1. Szeto HH, Birk AV. “Serendipity and the discovery of novel compounds that restore mitochondrial plasticity.” Clin Pharmacol Ther. 2014;96(6):672-683. PMID: 25188726
  2. Miller RA, et al. “NAD+ in aging and disease.” Science. 2023;382(6672):eabi4832. DOI: 10.1126/science.abi4832

Research use only. Materials are sold strictly for in vitro and qualified laboratory research. Not for human or veterinary use, diagnosis, or treatment. Full text: Research Use Statement.