CagriSema

What CagriSema is

CagriSema is a fixed-ratio combination of two separate, well-characterised research compounds: cagrilintide, a long-acting amylin (IAPP) analogue, and semaglutide, a long-acting GLP-1 receptor agonist. It is supplied as a single lyophilized material so that a defined molar ratio of the two peptides is delivered together — the configuration used to study amylin and incretin pathways acting in parallel rather than in isolation.

Two receptors, two complementary mechanisms

The research rationale is that the two peptides engage non-overlapping receptor systems with mechanisms that converge on the same metabolic endpoints:

Cagrilintide (amylin arm): agonist at the amylin receptor family (calcitonin-receptor / RAMP heterodimers AMY1–3). Studied for slowed gastric emptying, suppression of post-prandial glucagon, and central satiety via the area postrema and nucleus tractus solitarius.

Semaglutide (GLP-1 arm): agonist at the GLP-1 receptor (GLP-1R), a class-B Gs-coupled GPCR. Studied for glucose-dependent insulin secretion, hypothalamic appetite suppression (NPY/AgRP down, POMC/CART up), and slowed gastric emptying.

Because amylin acts primarily through brainstem circuits and GLP-1 through hypothalamic and pancreatic circuits, the combination is investigated for additive or complementary effects on food intake and metabolic regulation that neither pathway produces alone.

Research applications

CagriSema is studied in obesity and glycaemic-control model systems as a tool for dissecting the contribution of the amylin pathway on top of established GLP-1 receptor agonism. The fixed-ratio format controls relative exposure of the two components, which is useful when attributing an outcome to combined versus single-pathway activation. For the individual mechanisms, see the Cagrilintide guide and Semaglutide guide.

Identity and handling

Supplied lyophilized at ≥98% combined purity by HPLC with independent COA, as 2.5 + 2.5 mg (5 mg total). Both components are albumin-binding and long-acting; reconstitute in sterile bacteriostatic water (in-vivo work) or an appropriate buffer for cell culture, store −20 °C dry and 4 °C reconstituted ≤28 days, and avoid repeated freeze–thaw of the reconstituted blend.