Research use only (RUO): Qualified laboratory research only — not for human or veterinary use. Statement

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Research guide

HGH Fragment 176-191

GH C-terminal lipolytic fragment for adipose and fat metabolism research. ≥98% purity, COA. RUO only.

By · Reviewed · Editorial standards

Short answer

HGH Fragment 176-191 is supplied by HALO as a research-use-only lyophilized compound for qualified laboratory research. GH C-terminal lipolytic fragment for adipose and fat metabolism research. ≥98% purity, COA. RUO only.

  • Molecular weight: 1815.1 g/mol
  • CAS: 66004-57-7
  • Documentation: 98%+ HPLC purity, independent COA, lot-indexed records
  • Use limitation: Research use only; not for human or veterinary use

Diagrams

GHRHRGHSRGHIGF-1Research pathway (RUO model)
Research pathway context (schematic)
HALO · IDENTITYHGH Fragment 176-191CAS: 66004-57-7MW: 1815.1 g/molPurity ≥98% HPLC · Lyophilized · RUO only
Identity card
VialLot matchHPLCLC-MSBatch-specific COA chain
COA verification flow
Lyophilized handling (lab)−20 °CDry/sealed→Reconst.Diluent→2–8 °CShort holdResearch stock prep only · not dosing guidance
Lyophilized handling workflow

Mechanism of action in research models

HGH Fragment 176-191 is investigated in growth-hormone-axis research models spanning pituitary somatotroph cultures, hypothalamic GHRH neurons, ghrelin-responsive cells, and peripheral GH receptor signalling. GHRH analogues act through GHRHR to stimulate cAMP-mediated GH release, while GHRP-class peptides engage GHSR (ghrelin receptor) through a distinct pathway. Long-acting constructs may incorporate albumin binding or Fc fusion to extend exposure in pharmacokinetic studies.

Research programmes compare pulse amplitude, frequency, and selectivity (GH vs cortisol/prolactin co-release) across secretagogue classes. HALO materials are supplied only for qualified laboratory research — not for performance enhancement or human administration studies outside approved protocols.

Research background

The GH secretagogue literature distinguishes GHRH-pathway agonists, ghrelin mimetics, and downstream IGF-1 axis effectors. HGH Fragment 176-191 is used as a defined reference compound so laboratories can reproduce published assay conditions with batch-verified identity. Common endpoints include GH ELISA from supernatants, somatotroph calcium imaging, and receptor-binding displacement assays.

Documentation and COA standards

Each HALO lot of HGH Fragment 176-191 ships with an independent certificate of analysis documenting:

  • HPLC purity — reverse-phase chromatography with ≥98% main peak by area integration
  • Identity confirmation — LC-MS, ESI-MS, or MALDI-TOF as applicable to molecular weight
  • Lot / batch number — must match the vial label for procurement audit trails
  • Test date and method — third-party laboratory, not supplier self-reporting

Read: What is a peptide COA? · Batch-specific verification · Lab results index

Storage and handling

Store lyophilized HGH Fragment 176-191 sealed, cold (−20 °C), dry, and protected from light until reconstitution. After reconstitution with an appropriate research diluent, follow institutional stability protocols; minimise freeze-thaw cycles and document open-vial dates in the lab log.

Tools: Peptide calculator · Lyophilized peptide guide · Stability guide

Frequently asked research questions

What is HGH Fragment 176-191 used for in research?
HGH Fragment 176-191 is a research-use-only reference material studied in qualified laboratory models related to GHRHR / GHSR / GH-IGF-1 axis. HALO supplies it with batch COA documentation for procurement and methods citation. Not for human or veterinary use.
What documentation ships with HGH Fragment 176-191?
Each order includes a lot-specific certificate of analysis with HPLC purity, identity confirmation where applicable, batch number, and test date. Digital verification is available via the product page and /lab-results/.
How is purity verified for HGH Fragment 176-191?
Independent third-party HPLC confirms ≥98% main peak purity. Identity is confirmed by mass spectrometry when molecular weight permits. Results are lot-specific — not generic catalogue COAs.
What does RUO mean for this listing?
Research Use Only: HGH Fragment 176-191 is sold for qualified in-vitro and laboratory research. It is not for human or veterinary use, diagnosis, treatment, or clinical administration.
How should lyophilized HGH Fragment 176-191 be stored?
Keep sealed at −20 °C, desiccated, protected from light. After reconstitution, follow your institutional SOP; typical short-term storage is 2–8 °C with limited hold time depending on diluent and compound stability.
Where can the COA be verified?
Match the lot number on your vial to the COA on the product page or /lab-results/. For institutional packets email [email protected] with order number and lot ID.

Related research guides

  • Ipamorelin — Selective GHSR-1a agonist — pituitary GH secretion without ACTH/cortisol/prolactin activation.
  • CJC-1295 (No DAC) — DPP-IV-resistant GHRH(1-29) analogue — pulse-mimicking GHRHR agonist, ~30 min half-life.
  • Sermorelin — Native GHRH(1-29) — short-half-life reference GHRHR agonist for pituitary research.
  • Tesamorelin — Full-length GHRH(1-44) with fatty-acid N-terminal modification — intermediate half-life (~25–38 min).

Selected references

  1. Ghigo E, et al. “Growth hormone-releasing peptides.” Eur J Endocrinol. 1997;136(5):355-366. PMID: 9152677
  2. Teichman SL, et al. “Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295.” J Clin Endocrinol Metab. 2006;91(3):799-805. PMID: 16352683

Research use only. Materials are sold strictly for in vitro and qualified laboratory research. Not for human or veterinary use, diagnosis, or treatment. Full text: Research Use Statement.