Research use only (RUO): Qualified laboratory research only — not for human or veterinary use. Statement

Free shipping on orders over $200

HALO
Cart0

Research guide

KPV (Lys-Pro-Val)

Alpha-MSH C-terminal tripeptide for NF-κB and intestinal epithelial signalling research. ≥98% purity, COA. RUO only.

By · Reviewed · Editorial standards

Short answer

KPV (Lys-Pro-Val) is supplied by HALO as a research-use-only lyophilized compound for qualified laboratory research. Alpha-MSH C-terminal tripeptide for NF-κB and intestinal epithelial signalling research. ≥98% purity, COA. RUO only.

  • Molecular weight: 342.43 g/mol
  • Documentation: 98%+ HPLC purity, independent COA, lot-indexed records
  • Use limitation: Research use only; not for human or veterinary use

Diagrams

NO/eNOSVEGFR2ECMActinResearch pathway (RUO model)
Research pathway context (schematic)
HALO · IDENTITYKPV (Lys-Pro-Val)CAS: On COAMW: 342.43 g/molPurity ≥98% HPLC · Lyophilized · RUO only
Identity card
VialLot matchHPLCLC-MSBatch-specific COA chain
COA verification flow
Lyophilized handling (lab)−20 °CDry/sealed→Reconst.Diluent→2–8 °CShort holdResearch stock prep only · not dosing guidance
Lyophilized handling workflow

Mechanism of action in research models

KPV (Lys-Pro-Val) is studied in connective-tissue, extracellular-matrix, and tissue-remodelling research models. Pathways of interest include nitric-oxide/eNOS signalling, VEGFR2-mediated angiogenesis, actin cytoskeletal regulation, fibroblast migration, and inflammatory cytokine modulation. Preclinical models may use tendon fibroblast cultures, endothelial tube-formation assays, or controlled rodent injury models — always within institutional ethical approval.

Combination blends in this category are research preparations designed to study multi-pathway interactions in the same experimental system. HALO does not describe therapeutic outcomes; documentation emphasises identity, purity, and lot traceability for procurement files.

Research background

Connective-tissue peptide research examines how defined sequences influence cell migration, collagen organisation, and growth-factor expression in vitro. KPV (Lys-Pro-Val) should be treated as a characterised reference material: verify CAS/sequence on the COA, match lot numbers at receiving, and store lyophilized material per the stability notes below.

Documentation and COA standards

Each HALO lot of KPV (Lys-Pro-Val) ships with an independent certificate of analysis documenting:

  • HPLC purity — reverse-phase chromatography with ≥98% main peak by area integration
  • Identity confirmation — LC-MS, ESI-MS, or MALDI-TOF as applicable to molecular weight
  • Lot / batch number — must match the vial label for procurement audit trails
  • Test date and method — third-party laboratory, not supplier self-reporting

Read: What is a peptide COA? · Batch-specific verification · Lab results index

Storage and handling

Store lyophilized KPV (Lys-Pro-Val) sealed, cold (−20 °C), dry, and protected from light until reconstitution. After reconstitution with an appropriate research diluent, follow institutional stability protocols; minimise freeze-thaw cycles and document open-vial dates in the lab log.

Tools: Peptide calculator · Lyophilized peptide guide · Stability guide

Frequently asked research questions

What is KPV (Lys-Pro-Val) used for in research?
KPV (Lys-Pro-Val) is a research-use-only reference material studied in qualified laboratory models related to NO/eNOS · VEGFR2 · ECM · actin cytoskeleton. HALO supplies it with batch COA documentation for procurement and methods citation. Not for human or veterinary use.
What documentation ships with KPV (Lys-Pro-Val)?
Each order includes a lot-specific certificate of analysis with HPLC purity, identity confirmation where applicable, batch number, and test date. Digital verification is available via the product page and /lab-results/.
How is purity verified for KPV (Lys-Pro-Val)?
Independent third-party HPLC confirms ≥98% main peak purity. Identity is confirmed by mass spectrometry when molecular weight permits. Results are lot-specific — not generic catalogue COAs.
What does RUO mean for this listing?
Research Use Only: KPV (Lys-Pro-Val) is sold for qualified in-vitro and laboratory research. It is not for human or veterinary use, diagnosis, treatment, or clinical administration.
How should lyophilized KPV (Lys-Pro-Val) be stored?
Keep sealed at −20 °C, desiccated, protected from light. After reconstitution, follow your institutional SOP; typical short-term storage is 2–8 °C with limited hold time depending on diluent and compound stability.
Where can the COA be verified?
Match the lot number on your vial to the COA included with your shipment. For a digital copy or institutional packet, email [email protected] with your order number and lot ID.

Related research guides

  • BPC-157 — Synthetic pentadecapeptide — NO/eNOS, VEGFR2, EGR-1 signalling in connective-tissue research.
  • TB-500 — Thymosin β4 analogue — G-actin sequestration, PINCH-ILK-Akt survival, HIF-1α hypoxia response.
  • GHK-Cu — Copper tripeptide — collagen/ECM, MMP/TIMP, VEGF, Nrf2/ARE, anti-NF-κB in fibroblast research.

Selected references

  1. Gwyer D, et al. “Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing.” Cell Tissue Res. 2019;377(2):153-159. PMID: 30915550
  2. Chang CH, et al. “The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration.” J Appl Physiol. 2011;110(3):774-780. PMID: 21030672

Research use only. Materials are sold strictly for in vitro and qualified laboratory research. Not for human or veterinary use, diagnosis, or treatment. Full text: Research Use Statement.