Research use only (RUO): Qualified laboratory research only — not for human or veterinary use. Statement

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Research guide

Melanotan I (MT-1 / Afamelanotide)

Linear α-MSH analogue for melanocortin receptor and photoprotection research. ≥98% purity, COA. RUO only.

By · Reviewed · Editorial standards

Short answer

Melanotan I (MT-1 / Afamelanotide) is supplied by HALO as a research-use-only lyophilized compound for qualified laboratory research. Linear α-MSH analogue for melanocortin receptor and photoprotection research. ≥98% purity, COA. RUO only.

  • Molecular weight: 1646.9 g/mol
  • CAS: 75921-69-6
  • Documentation: 98%+ HPLC purity, independent COA, lot-indexed records
  • Use limitation: Research use only; not for human or veterinary use

Diagrams

ECMMC1RCopperFibroblaResearch pathway (RUO model)
Research pathway context (schematic)
HALO · IDENTITYMelanotan I (MT-1 / AfCAS: 75921-69-6MW: 1646.9 g/molPurity ≥98% HPLC · Lyophilized · RUO only
Identity card
VialLot matchHPLCLC-MSBatch-specific COA chain
COA verification flow
Lyophilized handling (lab)−20 °CDry/sealed→Reconst.Diluent→2–8 °CShort holdResearch stock prep only · not dosing guidance
Lyophilized handling workflow

Mechanism of action in research models

Melanotan I (MT-1 / Afamelanotide) is investigated in dermal fibroblast, keratinocyte, hair-follicle, and melanocyte research models. Copper tripeptides modulate lysyl oxidase and ECM gene expression; melanocortin analogues engage MC1R/MC4R pathways in pigmentation studies; SNARE-targeting peptides are tool compounds for neuromuscular junction and exocytosis research — not cosmetic treatment claims.

HALO frames aesthetic-cluster listings as laboratory research materials with full analytical documentation. No human-use or cosmetic outcome language applies.

Research background

Copper peptide and melanocortin research examines extracellular matrix remodelling, collagen synthesis markers, and receptor selectivity in cell-based assays. Melanotan I (MT-1 / Afamelanotide) batches ship with HPLC purity and identity confirmation suitable for institutional procurement review.

Documentation and COA standards

Each HALO lot of Melanotan I (MT-1 / Afamelanotide) ships with an independent certificate of analysis documenting:

  • HPLC purity — reverse-phase chromatography with ≥98% main peak by area integration
  • Identity confirmation — LC-MS, ESI-MS, or MALDI-TOF as applicable to molecular weight
  • Lot / batch number — must match the vial label for procurement audit trails
  • Test date and method — third-party laboratory, not supplier self-reporting

Read: What is a peptide COA? · Batch-specific verification · Lab results index

Storage and handling

Store lyophilized Melanotan I (MT-1 / Afamelanotide) sealed, cold (−20 °C), dry, and protected from light until reconstitution. After reconstitution with an appropriate research diluent, follow institutional stability protocols; minimise freeze-thaw cycles and document open-vial dates in the lab log.

Tools: Peptide calculator · Lyophilized peptide guide · Stability guide

Frequently asked research questions

What is Melanotan I (MT-1 / Afamelanotide) used for in research?
Melanotan I (MT-1 / Afamelanotide) is a research-use-only reference material studied in qualified laboratory models related to ECM · melanocortin · copper peptide · SNARE pathways. HALO supplies it with batch COA documentation for procurement and methods citation. Not for human or veterinary use.
What documentation ships with Melanotan I (MT-1 / Afamelanotide)?
Each order includes a lot-specific certificate of analysis with HPLC purity, identity confirmation where applicable, batch number, and test date. Digital verification is available via the product page and /lab-results/.
How is purity verified for Melanotan I (MT-1 / Afamelanotide)?
Independent third-party HPLC confirms ≥98% main peak purity. Identity is confirmed by mass spectrometry when molecular weight permits. Results are lot-specific — not generic catalogue COAs.
What does RUO mean for this listing?
Research Use Only: Melanotan I (MT-1 / Afamelanotide) is sold for qualified in-vitro and laboratory research. It is not for human or veterinary use, diagnosis, treatment, or clinical administration.
How should lyophilized Melanotan I (MT-1 / Afamelanotide) be stored?
Keep sealed at −20 °C, desiccated, protected from light. After reconstitution, follow your institutional SOP; typical short-term storage is 2–8 °C with limited hold time depending on diluent and compound stability.
Where can the COA be verified?
Match the lot number on your vial to the COA included with your shipment. For a digital copy or institutional packet, email [email protected] with your order number and lot ID.

Related research guides

  • GHK-Cu — Copper tripeptide — collagen/ECM, MMP/TIMP, VEGF, Nrf2/ARE, anti-NF-κB in fibroblast research.
  • AHK-Cu (Copper Tripeptide AHK) — Copper-chelating tripeptide for hair follicle and dermal signalling research. ≥98% purity, COA. RUO only.
  • SNAP-8 (Octapeptide-2) — Acetyl octapeptide targeting SNARE complex for neuromuscular junction research. ≥98% purity, COA. RUO only.

Selected references

  1. Pickart L, Margolina A. “Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data.” Int J Mol Sci. 2018;19(7):1987. PMID: 29986520

Research use only. Materials are sold strictly for in vitro and qualified laboratory research. Not for human or veterinary use, diagnosis, or treatment. Full text: Research Use Statement.